Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.53 |
| ▸ | RARG | P13631 | 11/20 | 0.53 |
| ▸ | RARA | P10276 | 10/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.52 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 3/20 | 0.46 |
| ▸ | RXRG | P48443 | 3/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9746761 | 1.00 | RARB (0.53) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9746364 | 0.88 | RARB (0.67) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL5712098 | 0.83 | RARB (0.75) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL5712126 | 0.83 | RARB (0.75) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9746403 | 0.83 | RARB (0.75) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL10541851 | 0.82 | RARB (0.58) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9746767 | 0.81 | RARA (0.52) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9746770 | 0.81 | RARA (0.52) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9747829 | 0.81 | RARB (0.56) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9747949 | 0.81 | RARB (0.71) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |