Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 3/20 | 0.52 |
| ▸ | ATP4B | P51164 | 3/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9746631 | 0.89 | PSEN1 (0.63) | ATP4AATP4BPSEN1PSEN2APH1B | |
| Iodide SCHEMBL9747550 | 0.89 | ATP4A (0.47) | ATP4AATP4BPSEN1PSEN2APH1B | |
| Iodide SCHEMBL9747969 | 0.88 | ATP4A (0.53) | ATP4AATP4BPSEN1PSEN2APH1B | |
| Iodide SCHEMBL10681165 | 0.88 | ATP4A (0.56) | ATP4AATP4BPSEN1PSEN2APH1B | |
| Iodide SCHEMBL9747520 | 0.88 | CYP1A2 (0.53) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| Iodide SCHEMBL10560824 | 0.85 | ATP4A (0.53) | ATP4AATP4BPSEN1PSEN2APH1B | |
| Iodide SCHEMBL9747346 | 0.84 | ATP4A (0.72) | ATP4AATP4BPSEN1PSEN2APH1B | |
| SCHEMBL9747746 | 0.83 | ATP4A (0.59) | ATP4AATP4BPSEN1PSEN2APH1B | |
| SCHEMBL9747050 | 0.83 | ATP4A (0.53) | ATP4AATP4BPSEN1PSEN2APH1B | |
| Iodide SCHEMBL9747136 | 0.83 | ATP4A (0.58) | ATP4AATP4BPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204285-B1 | IMIDAZOHETEROCYCLIC COMPOUNDS PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4725601-A | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0204285-A1 | Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-12-10 | — | — | EP | disclosed |