Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3563735 | 0.82 | ERN1 (0.61) | ERN1GAAL3MBTL1TDP1MAPT | |
| SCHEMBL11926109 | 0.80 | CA1 (0.36) | ERN1GAAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31674421 | 0.80 | MAPT (0.49) | ERN1GAAL3MBTL1TDP1ADRB2 | |
| SCHEMBL30071915 | 0.79 | ERN1 (0.51) | ERN1GAAL3MBTL1TDP1ADRB2 | |
| SCHEMBL5138904 | 0.78 | RAB9A (0.60) | ERN1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL29052130 | 0.78 | ERN1 (0.47) | ERN1GAAL3MBTL1TDP1MAPT | |
| SCHEMBL20563726 | 0.78 | ERN1 (0.50) | ERN1GAAL3MBTL1TDP1ADRB2 | |
| SCHEMBL8749413 | 0.78 | GAA (0.55) | ERN1GAAL3MBTL1TDP1ADRB2 | |
| SCHEMBL9484213 | 0.78 | GAA (0.55) | ERN1GAAL3MBTL1TDP1ADRB2 | |
| SCHEMBL29618406 | 0.77 | ERN1 (0.44) | ERN1GAAL3MBTL1TDP1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014141110-A2 | AMINONITRILES AS KYNURENINE PATHWAY INHIBITORS | CURADEV PHARMA PVT. LTD. (IN) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014141110-A2 | AMINONITRILES AS KYNURENINE PATHWAY INHIBITORS | CURADEV PHARMA PVT. LTD. (IN) | 2014-09-18 | — | — | WO | disclosed |
| EP-0201071-B1 | 2-SUBSTITUTED-1-NAPHTHOLS AS 5-LIPOXYGENASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-03-04 | — | — | EP | disclosed |
| US-5026759-A | Antiinflammatory agents respiratory system disorders | DU PONT MERCK PHARMACEUTICAL (US) | 1991-06-25 | — | — | US | disclosed |
| US-4985442-A | ANTIINFLAMMATORY, LUNG DISEASES, PSORIASIS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-15 | — | — | US | disclosed |
| US-4985435-A | TREATMENT OF INFLAMMATION, OBSTRUCTIVE LUNG DISEASES AND PSORIASIS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-15 | — | — | US | disclosed |
| US-4906636-A | 2-Substituted-1-naphthols as 5-lipoxygenase inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| US-4833164-A | ANTIINFLAMMATORY AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-05-23 | — | — | US | disclosed |
| EP-0201071-A2 | 2-Substituted-1-naphthols as 5-lipoxygenase inhibitors | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1986-11-12 | — | — | EP | disclosed |