Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749228 | 0.93 | ALDH1A1 (0.48) | KDM4EALDH1A1DRD3HSD17B10LMNA | |
| Danofloxacin SCHEMBL149627 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| Danofloxacin SCHEMBL10073753 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| Danofloxacin SCHEMBL9669908 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| Danofloxacin SCHEMBL29658817 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| Danofloxacin SCHEMBL16518619 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL9749598 | 0.84 | DRD3 (0.64) | KDM4EALDH1A1DRD3HSD17B10LMNA | |
| SCHEMBL9750333 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1DRD3HSD17B10LMNA | |
| Danofloxacin SCHEMBL28372629 | 0.84 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL9750291 | 0.82 | ALDH1A1 (0.48) | KDM4EALDH1A1DRD3HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |