Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9747349 | 0.91 | PTGS1 (0.43) | MAPTPTGS1PTGS2 | |
| SCHEMBL9747238 | 0.85 | MAPT (0.44) | MAPTNPC1MAPK1HTTPTGS1 | |
| SCHEMBL9747065 | 0.80 | PTGS1 (0.56) | MAPTNPC1MAPK1HTTPTGS1 | |
| SCHEMBL9748529 | 0.80 | PTGS1 (0.40) | PTGS1PTGS2 | |
| SCHEMBL22222824 | 0.79 | AKR1C3 (0.54) | MAPTNPC1MAPK1HTTPTGS1 | |
| SCHEMBL10395875 | 0.78 | MAPT (0.54) | MAPTNPC1MAPK1HTTPTGS1 | |
| SCHEMBL10396980 | 0.77 | MAPT (0.40) | MAPTNPC1MAPK1HTTPTGS1 | |
| SCHEMBL9747726 | 0.75 | NR4A1 (0.49) | MAPTMAPK1PTGS1PTGS2ABCB11 | |
| SCHEMBL9747494 | 0.74 | ABCB11 (0.65) | PTGS1PTGS2ABCB11LMNAADORA1 | |
| SCHEMBL9748269 | 0.74 | NR4A1 (0.48) | MAPTMAPK1PTGS1PTGS2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | claimed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | claimed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | claimed |