Sugi Predict

Sugi Predict / Compounds / SCHEMBL974878

SCHEMBL974878

SCHEMBL974878

Fc1cnc2ncccc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CA P42336 1/20 0.43
▸ BCHE P06276 1/20 0.42
▸ ACHE P22303 1/20 0.42
▸ SLC40A1 Q9NP59 4/20 0.40
▸ ACP1 P24666 1/20 0.40
▸ CCR1 P32246 2/20 0.39
▸ CCR5 P51681 2/20 0.39
▸ CCR8 P51685 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ GMNN O75496 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ TP53 P04637 1/20 0.38
▸ HSP90AA1 P07900 1/20 0.38
▸ MMP2 P08253 1/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ CYP2D6 P10635 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ MMP9 P14780 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1519321 0.75 NR4A2 (0.47) PIK3CASLC40A1ACP1CCR1CCR5
SCHEMBL2007648 0.75 ACP1 (0.40) PIK3CAACP1CCR1CCR5CCR8
SCHEMBL30468180 0.75 ACP1 (0.40) PIK3CAACP1CCR1CCR5CCR8
SCHEMBL2619133 0.75 CCR1 (0.67) BCHEACHESLC40A1ACP1CCR1
SCHEMBL276491 0.75 ACP1 (0.43) PIK3CAACP1CCR1CCR5CCR8
SCHEMBL30283008 0.75 MAPT (0.52) ACP1CCR1CCR5CCR8KDM4E
SCHEMBL169260 0.75 MAPT (0.52) ACP1CCR1CCR5CCR8KDM4E
SCHEMBL29862389 0.75 HTT (0.47) ACP1CCR1CCR5CCR8KDM4E
SCHEMBL18459627 0.75 ACP1 (0.40) PIK3CAACP1CCR1CCR5CCR8
SCHEMBL29859744 0.75 MAPT (0.52) ACP1CCR1CCR5CCR8KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1083063-A 6-fluoro-1, the improvement method for making of 8-7-naphthyridine derivatives XINHUA PHARMACEUTICAL FACTORY (CN) 1994-03-02 — — CN claimed
JP-59080683-A — — None — — JP disclosed
CN-102006777-B Herbicidal compounds SYNGENTA LTD 2015-04-01 — — CN disclosed
US-8461083-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2013-06-11 — — US disclosed
CN-102006777-A Herbicidal coumpounds SYNGENTA LTD 2011-04-06 — — CN disclosed
US-20110021352-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-01-27 — — US disclosed
US-20100087409-A1 COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID INTERVET INTERNATIONAL BV 2010-04-08 — — US disclosed
US-7432279-B2 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same WYETH (US) 2008-10-07 — — US disclosed
EP-1881981-A1 4, 6-DIAMINO-[1,7] NAPHTHYRIDINE-3-CARBONITRILE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME Wyeth (US) 2008-01-30 — — EP disclosed
US-20060276498-A1 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same WYETH (US) 2006-12-07 — — US disclosed
WO-2004058144-A2 ANTIBACTERIAL AGENTS GLAXO GROUP LIMITED (GB) 2004-07-15 — — WO disclosed
CN-1083063-A 6-fluoro-1, the improvement method for making of 8-7-naphthyridine derivatives XINHUA PHARMACEUTICAL FACTORY (CN) 1994-03-02 — — CN disclosed
US-4659734-A BACTERICIDES, FUNGICIDES NIPPON SHINYAKU CO., LTD. (JP) 1987-04-21 — — US disclosed
EP-0058392-B1 SUBSTITUTED CARBOXYLIC ACID DERIVATIVES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1985-11-21 — — EP disclosed
JP-S5980683-A 6-FLUORO-1,8-NAPHTHYRIDINE DERIVATIVE AND ITS PREPARATION KOEI CHEM CO LTD 1984-05-10 — — JP disclosed
US-4426381-A 1,4-DIHYDROQUINOLIN-4-ONES, FUNGICIDES, BACTERICIDES NIPPON SHINYAKU CO., LTD. (JP) 1984-01-17 — — US disclosed
EP-0027752-B1 NAPHTHYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Société anonyme dite: LABORATOIRE ROGER BELLON (FR) 1983-12-21 — — EP disclosed
EP-0058392-A1 Substituted carboxylic acid derivatives NIPPON SHINYAKU COMPANY, LIMITED (JP) 1982-08-25 — — EP disclosed
US-4341784-A BACTERICIDES DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1982-07-27 — — US disclosed
EP-0027752-A1 Naphthyridine derivatives, processes for their preparation and pharmaceutical compositions containing them Société anonyme dite: LABORATOIRE ROGER BELLON (FR) 1981-04-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276498-A1 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same TNNI3K, CNKSR1, DTYMK PIK3CA 643/4885BCHE 2138/4885ACHE 1380/4885
US-20100087409-A1 COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID CYP21A2, CYP27A1, NR3C2 PIK3CA 285/4885BCHE 2862/4885ACHE 2163/4885
US-20110021352-A1 HERBICIDAL COMPOUNDS RDX, NQO2, DDT PIK3CA 1994/4885BCHE 260/4885ACHE 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.