Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | TOP2A | P11388 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670452 | 0.96 | KDM4E (0.70) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9669533 | 0.92 | KDM4E (0.67) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9671823 | 0.92 | KDM4E (0.67) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9701127 | 0.90 | KDM4E (0.74) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10817829 | 0.88 | KDM4E (0.71) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9365382 | 0.88 | KDM4E (0.73) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9184531 | 0.87 | KDM4E (0.72) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9665892 | 0.87 | ALDH1A1 (0.72) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10755985 | 0.87 | KDM4E (0.55) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9748540 | 0.86 | KDM4E (0.71) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| CN-1014789-B | PROCESS FOR PREPARING REPLACABLE BRIDGED HEAVY NITROGEN BICYCLOALKYL CARBOSTYRIL CARBOXYLIC ACID | PFIZER (US) | 1991-11-20 | — | — | CN | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0230274-A2 | Derivatives of 7-(azabicycloalkyl)-quinoloncarboxylic acid and -naphthyridoncarboxylic acid | BAYER AG (DE) | 1987-07-29 | — | — | EP | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |