Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.73 |
| ▸ | TEK | Q02763 | 3/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489788 | 0.89 | PDE10A (0.75) | PDE10ATEKKDR | |
| SCHEMBL2489337 | 0.86 | PDE10A (0.83) | PDE10ATEKKDR | |
| SCHEMBL14804947 | 0.84 | PDE10A (1.00) | PDE10ATEK | |
| SCHEMBL972866 | 0.83 | PDE10A (0.76) | PDE10ATEK | |
| SCHEMBL2486389 | 0.83 | PDE10A (0.58) | PDE10A | |
| SCHEMBL974493 | 0.82 | TEK (1.00) | PDE10ATEKKDR | |
| SCHEMBL2482411 | 0.82 | — | — | |
| SCHEMBL2487456 | 0.82 | PDE10A (0.79) | PDE10ATEKKDR | |
| SCHEMBL2489359 | 0.82 | PDE10A (1.00) | PDE10ATEKKDR | |
| SCHEMBL972433 | 0.81 | PDE10A (0.77) | PDE10ATEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | disclosed |