Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430068 | 0.83 | SLC6A2 (0.33) | HDAC1HDAC8HDAC6KCNH2 | |
| SCHEMBL13429743 | 0.83 | KCNH2 (0.41) | HDAC1HDAC8HDAC6MAOAMAOB | |
| SCHEMBL13430114 | 0.83 | KCNH2 (0.41) | HDAC1HDAC8HDAC6MAOAMAOB | |
| SCHEMBL13429778 | 0.79 | MAOA (0.50) | MAOAMAOBCYP2C19KCNH2F10 | |
| SCHEMBL9964928 | 0.79 | MAOA (0.50) | MAOAMAOBCYP2C19KCNH2F10 | |
| SCHEMBL9091911 | 0.79 | MAOA (0.50) | MAOAMAOBCYP2C19KCNH2F10 | |
| SCHEMBL9093150 | 0.79 | MAOA (0.50) | MAOAMAOBCYP2C19KCNH2F10 | |
| SCHEMBL3222830 | 0.79 | MAOA (0.50) | MAOAMAOBCYP2C19KCNH2F10 | |
| SCHEMBL13430105 | 0.77 | MAOA (0.40) | MAOAMAOBCYP2C19KCNH2F10 | |
| SCHEMBL13429570 | 0.75 | F10 (0.40) | MAOAMAOBCYP2C19KCNH2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500686-A1 | TRICYCLIC 6,5,5]/ 6,6,5]-FUSED OXAZOLIDINONE ANTIBACTERIAL AGENTS. | UPJOHN CO (US) | 1992-09-02 | — | — | EP | disclosed |
| WO-1991007409-A1 | TRICYCLIC [6,5,5]/[6,6,5]-FUSED OXAZOLIDINONE ANTIBACTERIAL AGENTS | THE UPJOHN COMPANY (US) | 1991-05-30 | — | — | WO | disclosed |