Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837350 | 0.92 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9685908 | 0.85 | ALDH1A1 (0.44) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9684708 | 0.85 | ALDH1A1 (0.44) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9748481 | 0.84 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9670968 | 0.84 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9749598 | 0.84 | DRD3 (0.64) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9837602 | 0.83 | HSD17B10 (0.64) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9481281 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL10480257 | 0.82 | DRD3 (0.63) | KDM4EALDH1A1HSD17B10HPGDHTT | |
| SCHEMBL9749610 | 0.82 | DRD3 (0.63) | KDM4EALDH1A1HSD17B10HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| CN-1014789-B | PROCESS FOR PREPARING REPLACABLE BRIDGED HEAVY NITROGEN BICYCLOALKYL CARBOSTYRIL CARBOXYLIC ACID | PFIZER (US) | 1991-11-20 | — | — | CN | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |