Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9749993 | 1.00 | GRIK1 (0.52) | GRIK1GRIK2BCHEMAOBAPP | |
| Bromide SCHEMBL2449961 | 0.81 | HTR2A (0.50) | GRIK1GRIK2 | |
| Bromide SCHEMBL2449964 | 0.81 | HTR2A (0.50) | GRIK1GRIK2 | |
| Hydrochloric Acid SCHEMBL2452749 | 0.77 | HTR2A (0.50) | GRIK1GRIK2 | |
| Water SCHEMBL8528187 | 0.77 | HTR2A (0.50) | GRIK1GRIK2 | |
| Water SCHEMBL8528185 | 0.77 | HTR2A (0.50) | GRIK1GRIK2 | |
| Hydrochloric Acid SCHEMBL2452746 | 0.77 | HTR2A (0.50) | GRIK1GRIK2 | |
| SCHEMBL3103681 | 0.75 | GRIK1 (0.68) | GRIK1GRIK2BCHEMAOBAPP | |
| SCHEMBL3103688 | 0.75 | GRIK1 (0.68) | GRIK1GRIK2BCHEMAOBAPP | |
| SCHEMBL3846090 | 0.75 | MAPT (0.53) | GRIK1GRIK2BCHEMAOBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63141947-A | — | — | None | — | — | JP | disclosed |
| JP-63141952-A | — | — | None | — | — | JP | disclosed |
| US-5081233-A | Charge generating compounds | RICOH COMPANY, LTD. (JP) | 1992-01-14 | — | — | US | disclosed |
| US-4830943-A | Bisazo compounds and electrophotographic photoconductors comprising the bisazo compounds | RICOH COMPANY, LTD. (JP) | 1989-05-16 | — | — | US | disclosed |
| JP-S63141952-A | NOVEL TETRAZOLIUM SALT COMPOUND AND PRODUCTION THEREOF | RICOH CO LTD | 1988-06-14 | — | — | JP | disclosed |
| JP-S63141947-A | 1,12-BIS(4-AMINOPHENYL)-1,3,5,7,9,11-DODECAHEXAENE AND PRODUCTION THEREOF | RICOH CO LTD | 1988-06-14 | — | — | JP | disclosed |