SCHEMBL9751081

SCHEMBL9751081

CCCOC(=O)/C=C/C(=O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.59
HCAR2 Q8TDS4 6/20 0.58
MAPT P10636 3/20 0.56
AKT1 P31749 2/20 0.50
ALDH1A1 P00352 1/20 0.47
ATM Q13315 1/20 0.47
RAB9A P51151 3/20 0.47
KMT2A Q03164 2/20 0.47
NPC1 O15118 2/20 0.47
APP P05067 1/20 0.47
RECQL P46063 2/20 0.46
MEN1 O00255 1/20 0.46
MAPK1 P28482 1/20 0.46
CASP3 P42574 1/20 0.45
SENP8 Q96LD8 1/20 0.45
SENP7 Q9BQF6 1/20 0.45
SENP6 Q9GZR1 1/20 0.45
PLIN1 O60240 1/20 0.44
BCHE P06276 1/20 0.44
TNFRSF1A P19438 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10957082 0.90 ATM (0.62) LMNAHCAR2MAPTAKT1ATM
SCHEMBL10957079 0.90 ATM (0.62) LMNAHCAR2MAPTAKT1ATM
SCHEMBL9391347 0.90 HCAR2 (0.59) LMNAHCAR2MAPTAKT1ALDH1A1
SCHEMBL9389460 0.90 HCAR2 (0.59) LMNAHCAR2MAPTAKT1ALDH1A1
SCHEMBL30319473 0.88 HCAR2 (0.62) LMNAHCAR2MAPTALDH1A1ATM
SCHEMBL3372572 0.86 MAPT (0.72) LMNAHCAR2MAPTAKT1ALDH1A1
SCHEMBL3371348 0.86 MAPT (0.72) LMNAHCAR2MAPTAKT1ALDH1A1
SCHEMBL9751109 0.86 MAPT (0.72) LMNAHCAR2MAPTAKT1ALDH1A1
Isophthalic Acid SCHEMBL28926291 0.82 KMT2A (0.58) LMNAHCAR2ATMKMT2AAPP
SCHEMBL29031678 0.81 HCAR2 (0.59) LMNAHCAR2MAPTALDH1A1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0204286-B1 PROCESS FOR PREPARING TRANS-BETA-BENZOYLACRYLIC ACID ESTER KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-12-11 EP disclosed
US-4994600-A Process for preparing trans-β-benzoylacrylic acid ester KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-02-19 US disclosed
EP-0204286-A2 Process for preparing trans-beta-benzoylacrylic acid ester KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-12-10 EP disclosed