SCHEMBL9751109

SCHEMBL9751109

CCOC(=O)/C=C\C(=O)c1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.72
RAB9A P51151 4/20 0.55
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
HCAR2 Q8TDS4 1/20 0.55
MAPK1 P28482 1/20 0.55
CASP3 P42574 1/20 0.54
SENP8 Q96LD8 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
SENP6 Q9GZR1 1/20 0.54
AKT1 P31749 2/20 0.53
LMNA P02545 3/20 0.53
NPC1 O15118 3/20 0.53
MDM2 Q00987 2/20 0.53
MDM4 O15151 1/20 0.52
ALDH1A1 P00352 3/20 0.51
THRB P10828 1/20 0.51
PTGS2 P35354 1/20 0.51
NPSR1 Q6W5P4 1/20 0.50
PKM P14618 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3371348 1.00 MAPT (0.72) MAPTRAB9AKMT2AMEN1HCAR2
SCHEMBL3372572 1.00 MAPT (0.72) MAPTRAB9AKMT2AMEN1HCAR2
SCHEMBL27866339 0.92 MAPT (0.63) MAPTRAB9AKMT2AMEN1HCAR2
SCHEMBL11020467 0.88 MAPT (0.65) MAPTRAB9AKMT2AMEN1HCAR2
SCHEMBL11020465 0.88 MAPT (0.65) MAPTRAB9AKMT2AMEN1HCAR2
Diethyl Maleate SCHEMBL11324124 0.87 MAPT (0.60) MAPTRAB9AKMT2AMEN1HCAR2
SCHEMBL9751081 0.86 LMNA (0.59) MAPTRAB9AKMT2AMEN1HCAR2
SCHEMBL14601551 0.86 ALDH1A1 (0.68) MAPTRAB9AKMT2AMEN1HCAR2
SCHEMBL28789132 0.86 ALDH1A1 (0.68) MAPTRAB9AKMT2AMEN1HCAR2
Chalcone SCHEMBL5079939 0.85 MAPT (0.67) MAPTRAB9AKMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4925969-A MICHAEL ADDITION, ALANINE OR LYSINE DERIVATIVE REACTED WITH ETHYL BENZOYLACRYLATE KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1990-05-15 US claimed
EP-0190687-B1 PROCESS FOR PREPARING ETHYL-ALPHA-(1-CARBOXYETHYL)-AMINO-GAMMA-OXO-GAMMA-PHENYLBUTYRATE KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-10-05 EP claimed
CN-110487931-B Analysis method of (E) -4-phenyl-4-oxo-2-ethyl butenoate 浙江华海药业股份有限公司 2024-10-01 CN disclosed
EP-0204286-B1 PROCESS FOR PREPARING TRANS-BETA-BENZOYLACRYLIC ACID ESTER KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-12-11 EP disclosed
US-5061722-A Hypotensive agents; e.g. ramipril HOECHST AG (DE) 1991-10-29 US disclosed
US-4994600-A Process for preparing trans-β-benzoylacrylic acid ester KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-02-19 US disclosed
US-4925969-A MICHAEL ADDITION, ALANINE OR LYSINE DERIVATIVE REACTED WITH ETHYL BENZOYLACRYLATE KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1990-05-15 US disclosed
EP-0190687-B1 PROCESS FOR PREPARING ETHYL-ALPHA-(1-CARBOXYETHYL)-AMINO-GAMMA-OXO-GAMMA-PHENYLBUTYRATE KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-10-05 EP disclosed
EP-0204286-A2 Process for preparing trans-beta-benzoylacrylic acid ester KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-12-10 EP disclosed
EP-0190687-A1 Process for preparing ethyl-alpha-(1-carboxyethyl)-amino-gamma-oxo-gamma-phenylbutyrate KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-08-13 EP disclosed
EP-0190687-A1 Process for preparing ethyl-alpha-(1-carboxyethyl)-amino-gamma-oxo-gamma-phenylbutyrate KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-08-13 EP disclosed