Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8582363 | 0.75 | IDO1 (0.49) | MEN1KMT2A | |
| SCHEMBL562868 | 0.72 | CYP2A6 (0.39) | L3MBTL1CYP2A6SIGMAR1MEN1KMT2A | |
| SCHEMBL6583705 | 0.70 | POLB (0.37) | CYP2A6MEN1KMT2ACYP2C19HRH4 | |
| SCHEMBL1036360 | 0.70 | LMNA (0.34) | SIGMAR1KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10978597 | 0.69 | CYP2A6 (0.46) | CYP2A6ADRB2ASIC3LOXL2DRD2 | |
| SCHEMBL6481877 | 0.68 | CYP2A6 (0.47) | CYP2A6SIGMAR1ADRB2HDAC3HDAC4 | |
| SCHEMBL7099438 | 0.68 | KDM4E (0.48) | MEN1KMT2ANPSR1 | |
| SCHEMBL9754305 | 0.65 | CYP2A6 (0.44) | CYP2A6SIGMAR1ADRB2HDAC3HDAC4 | |
| SCHEMBL6642084 | 0.65 | CYP2A6 (0.44) | CYP2A6SIGMAR1ADRB2HDAC3HDAC4 | |
| SCHEMBL2494058 | 0.65 | CYP2A6 (0.53) | CYP2A6ADRB2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422119-A4 | BENZOTHIOPHENE DERIVATIVES USEFUL FOR MODIFYING FEEDING BEHAVIOR AND OBSESSIVE-COMPULSIVE BEHAVIOR | — | 1991-11-13 | — | — | EP | disclosed |
| EP-0422119-A1 | BENZOTHIOPHENE DERIVATIVES USEFUL FOR MODIFYING FEEDING BEHAVIOR AND OBSESSIVE-COMPULSIVE BEHAVIOR | NEUREX CORPORATION (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4971974-A | ANOREXIGENIC AGENTS, BENZO B!THIENO 2,3-C!PYRIDINE COMPOUNDS | NEUREX CORPORATION (US) | 1990-11-20 | — | — | US | disclosed |
| WO-1989012447-A1 | BENZOTHIOPHENE DERIVATIVES USEFUL FOR MODIFYING FEEDING BEHAVIOR AND OBSESSIVE-COMPULSIVE BEHAVIOR | NEUREX CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |