Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 18/20 | 0.45 |
| ▸ | AKR1A1 | P14550 | 17/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9674175 | 0.78 | AKR1A1 (0.60) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9674037 | 0.78 | AKR1B1 (0.48) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9672265 | 0.76 | AKR1B1 (0.51) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL20845828 | 0.71 | AKR1A1 (0.72) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9671730 | 0.70 | AKR1A1 (0.48) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9751281 | 0.70 | AKR1A1 (0.66) | AKR1B1AKR1A1 | |
| SCHEMBL9751204 | 0.70 | AKR1A1 (0.66) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9672184 | 0.68 | AKR1B1 (0.46) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9672199 | 0.68 | AKR1A1 (0.71) | AKR1B1AKR1A1 | |
| SCHEMBL5953411 | 0.66 | AKR1A1 (0.53) | AKR1B1AKR1A1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306525-A4 | USE OF ALDOSE REDUCTASE INHIBITORS TO ENHANCE INSULIN SENSITIVITY IN DIABETES MELLITUS | — | 1991-04-24 | — | — | EP | disclosed |
| EP-0306525-A1 | USE OF ALDOSE REDUCTASE INHIBITORS TO ENHANCE INSULIN SENSITIVITY IN DIABETES MELLITUS | ALCON LABORATORIES, INC. (US) | 1989-03-15 | — | — | EP | disclosed |
| WO-1988006887-A1 | USE OF ALDOSE REDUCTASE INHIBITORS TO ENHANCE INSULIN SENSITIVITY IN DIABETES MELLITUS | ALCON LABORATORIES, INC. (US) | 1988-09-22 | — | — | WO | disclosed |