Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.71 |
| ▸ | DRD3 | P35462 | 14/20 | 0.71 |
| ▸ | DRD4 | P21917 | 4/20 | 0.71 |
| ▸ | HTR1D | P28221 | 6/20 | 0.56 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630806 | 0.89 | DRD2 (0.60) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8631318 | 0.89 | DRD2 (0.60) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8630810 | 0.89 | DRD2 (0.60) | DRD2DRD3DRD4HTR1DHTR1B | |
| Ammonia Solution, Strong SCHEMBL9759247 | 0.87 | DRD2 (0.59) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL14422957 | 0.84 | DRD2 (0.72) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL14847040 | 0.83 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL17446169 | 0.83 | DRD2 (1.00) | DRD2DRD3DRD4HTR1D | |
| SCHEMBL1682783 | 0.83 | DRD2 (1.00) | DRD2DRD3DRD4HTR1D | |
| SCHEMBL1682786 | 0.83 | DRD2 (1.00) | DRD2DRD3DRD4HTR1D | |
| SCHEMBL7327300 | 0.83 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452390-A1 | HALO SUBSTITUTED AMINOTETRALINS. | UPJOHN CO (US) | 1991-10-23 | — | — | EP | claimed |
| WO-1990007490-A1 | HALO SUBSTITUTED AMINOTETRALINS | THE UPJOHN COMPANY (US) | 1990-07-12 | — | — | WO | claimed |