Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.67 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexanone SCHEMBL4919079 | 0.90 | GSR (0.48) | GSRARG2ARG1GRIK1GRIA1 | |
| Lysine SCHEMBL23728835 | 0.88 | GSR (0.87) | GSRARG2ARG1GRIK1RNPEP | |
| Lysine SCHEMBL18986644 | 0.88 | GSR (0.87) | GSRARG2ARG1GRIK1RNPEP | |
| Lysine SCHEMBL20567629 | 0.87 | GSR (0.67) | GSRARG2ARG1GRIK1RNPEP | |
| Lysine SCHEMBL7973655 | 0.84 | GSR (0.95) | GSRARG2ARG1GRIK1RNPEP | |
| Lysine SCHEMBL7973663 | 0.84 | GSR (0.95) | GSRARG2ARG1GRIK1RNPEP | |
| Ornithine Aketoglutarate SCHEMBL28343603 | 0.82 | GSR (0.75) | GSRARG2ARG1GRIK1GRIA1 | |
| Ornithine Aketoglutarate SCHEMBL28614002 | 0.82 | GSR (0.75) | GSRARG2ARG1GRIK1GRIA1 | |
| Lysine SCHEMBL9439278 | 0.82 | GSR (1.00) | GSRARG2ARG1GRIK1RNPEP | |
| Lysine SCHEMBL20362357 | 0.82 | GSR (1.00) | GSRARG2ARG1GRIK1RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3031366-A | — | — | None | — | — | JP | disclosed |
| JP-H0331366-A | SYNTHETIC RESIN COMPOSITION | AJINOMOTO CO INC | 1991-02-12 | — | — | JP | disclosed |