Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752143 | 1.00 | MTNR1A (0.50) | MTNR1AMTNR1BNR1H2CA1CA2 | |
| SCHEMBL17478343 | 0.95 | CA1 (0.47) | MTNR1AMTNR1BNR1H2CA1CA2 | |
| SCHEMBL13263584 | 0.95 | CA1 (0.47) | MTNR1AMTNR1BNR1H2CA1CA2 | |
| SCHEMBL17478424 | 0.95 | CA1 (0.47) | MTNR1AMTNR1BNR1H2CA1CA2 | |
| SCHEMBL5598167 | 0.89 | EPHX2 (0.50) | NR1H2CA1CA2EPHX2DRD2 | |
| SCHEMBL5677299 | 0.86 | CA1 (0.64) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL5722246 | 0.86 | CA1 (0.64) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9136687 | 0.86 | CA1 (0.64) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL464262 | 0.85 | MTNR1A (0.50) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9132121 | 0.82 | MTNR1A (0.48) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5053430-A | For treating schizophrenia | BOEHRINGER INGELHEIM KG (DE) | 1991-10-01 | — | — | US | disclosed |
| EP-0435988-A1 | 2-AMINO-7-CARBAMOYL-1,2,3,4-TETRAHYDRONAPHTHALENES, PROCESS FOR PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM KG (DE) | 1991-07-10 | — | — | EP | disclosed |
| WO-1991001297-A1 | 2-AMINO-7-CARBAMOYL-1,2,3,4-TETRAHYDRONAPHTHALENES, PROCESS FOR PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM KG (DE) | 1991-02-07 | — | — | WO | disclosed |
| EP-0361300-A1 | Use of 2,7 diamino-1,2,3,4-tetrahydronaphthalenes as drugs, 2,7 diamino-1,2,3,4-tetrahydronaphthalenes as well as processes for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1990-04-04 | — | — | EP | disclosed |