Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714032 | 0.90 | ALDH1A1 (0.56) | CYP1A2CYP3A4CYP2D6MAPTCYP2C9 | |
| SCHEMBL9468482 | 0.88 | MAPT (0.62) | CYP1A2CYP3A4CYP2D6MAPTCYP2C9 | |
| SCHEMBL2702706 | 0.87 | NPC1 (0.53) | MAPTHTTTOP2AALDH1A1KMT2A | |
| SCHEMBL11379071 | 0.86 | MAPT (0.53) | CYP1A2CYP3A4CYP2D6MAPTCYP2C9 | |
| SCHEMBL10654010 | 0.85 | TOP2A (0.48) | CYP1A2CYP3A4CYP2D6MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL6225430 | 0.85 | NPC1 (0.52) | MAPTHTTTOP2AALDH1A1KMT2A | |
| SCHEMBL1751588 | 0.85 | MAPT (0.56) | MAPTHTTTOP2AGAAALDH1A1 | |
| SCHEMBL2542902 | 0.85 | EGFR (0.56) | CYP1A2CYP3A4MAPTCYP2C19HTT | |
| SCHEMBL5044675 | 0.85 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6MAPTCYP2C9 | |
| SCHEMBL8168563 | 0.84 | MAPT (0.53) | CYP1A2CYP3A4CYP2D6MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101058558-A | 4-Oxy-1(4H)-quinoline carboxylic acids compound and composition with aldose reductase inhibition activity and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2007-10-24 | — | — | CN | claimed |
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| CN-101058558-A | 4-Oxy-1(4H)-quinoline carboxylic acids compound and composition with aldose reductase inhibition activity and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2007-10-24 | — | — | CN | disclosed |
| EP-0462262-A1 | COPOLYMERIZED METHINE COLORANT-POLYESTER COLOR CONCENTRATES | EASTMAN CHEMICAL COMPANY (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991010693-A1 | COPOLYMERIZED METHINE COLORANT-POLYESTER COLOR CONCENTRATES | EASTMAN KODAK COMPANY (US) | 1991-07-25 | — | — | WO | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |