Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21084 | 0.91 | ALDH1A1 (0.54) | ALDH1A1TRPA1TTRGABRA1GABRB2 | |
| SCHEMBL28396990 | 0.89 | ALDH1A1 (0.52) | ALDH1A1TRPA1TTRGABRA1GABRB2 | |
| Ammonia Solution, Strong SCHEMBL7744383 | 0.89 | ALDH1A1 (0.52) | ALDH1A1TRPA1TTRGABRA1GABRB2 | |
| Water SCHEMBL3630768 | 0.89 | ALDH1A1 (0.52) | ALDH1A1TRPA1TTRGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL9814070 | 0.89 | ALDH1A1 (0.52) | ALDH1A1TRPA1TTRGABRA1GABRB2 | |
| Formaldehyde SCHEMBL958921 | 0.87 | ALDH1A1 (0.50) | ALDH1A1TRPA1TTRGABRA1GABRB2 | |
| Ethylenediamine SCHEMBL18107074 | 0.86 | ALDH1A1 (0.45) | ALDH1A1TRPA1TTRGABRA1GABRB2 | |
| Guanidine SCHEMBL3281031 | 0.84 | TTR (0.42) | ALDH1A1TRPA1TTRF2PLAU | |
| Guanidine SCHEMBL811269 | 0.83 | MYC (0.46) | ALDH1A1TTRF2KDM4EMYC | |
| Pyridine SCHEMBL5570325 | 0.83 | ALDH1A1 (0.42) | ALDH1A1TRPA1TTRGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991000329-A1 | PROCESS FOR THE TREATMENT OF USED OIL | GEUT AG GESELLSCHAFT FÜR ENERGIE- UND UMWELTTECHNIK (CH) | 1991-01-10 | — | — | WO | disclosed |