Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9355072 | 0.91 | TDP1 (0.35) | TSHRHSD17B10TDP1 | |
| SCHEMBL8765345 | 0.78 | TET2 (0.42) | ALDH1A1TSHRHSD17B10TDP1 | |
| SCHEMBL9251625 | 0.77 | — | — | |
| SCHEMBL543679 | 0.77 | TSHR (0.38) | ALDH1A1TSHRHSD17B10TDP1 | |
| SCHEMBL27814091 | 0.77 | TSHR (0.35) | TSHRTDP1 | |
| SCHEMBL28593358 | 0.77 | TDP1 (0.35) | ALDH1A1TSHRHSD17B10TDP1 | |
| Bicarbonate SCHEMBL29012820 | 0.74 | TSHR (0.32) | ALDH1A1TSHRHSD17B10TDP1 | |
| SCHEMBL7691524 | 0.74 | — | — | |
| SCHEMBL9066247 | 0.73 | TSHR (0.32) | ALDH1A1TSHRHSD17B10TDP1 | |
| SCHEMBL8048756 | 0.71 | ALDH1A1 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991000301-A1 | (CO)POLYMER MODIFICATION EMPLOYING UNSATURATED t-ALKYL PEROXYALKENYL CARBONATES | AKZO N.V. (NL) | 1991-01-10 | — | — | WO | disclosed |