Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.48 |
| ▸ | KLK1 | P06870 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | VEGFA | P15692 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768170 | 0.93 | POLB (0.61) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1240350 | 0.92 | MAPT (0.56) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL4591947 | 0.92 | POLB (0.61) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16881026 | 0.92 | POLB (0.56) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9523272 | 0.91 | KDM4E (0.60) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16891528 | 0.90 | MAPT (0.61) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL15873869 | 0.90 | POLB (0.54) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16891381 | 0.90 | POLB (0.54) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16881558 | 0.90 | POLB (0.54) | POLBNPSR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16246832 | 0.90 | POLB (0.54) | POLBNPSR1L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991009848-A1 | PYRIDINONES USEFUL AS ANTIATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | claimed |