Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091786 | 0.89 | SIGMAR1 (0.60) | SIGMAR1KCNH2KMT2AMEN1 | |
| SCHEMBL9752779 | 0.85 | SIGMAR1 (0.51) | SIGMAR1KCNH2KMT2AMEN1NPC1 | |
| SCHEMBL8099094 | 0.85 | SIGMAR1 (0.57) | SIGMAR1KCNH2KMT2AMEN1NPC1 | |
| SCHEMBL9378576 | 0.85 | SIGMAR1 (0.56) | SIGMAR1KCNH2KMT2AMEN1CYP2D6 | |
| SCHEMBL8096269 | 0.85 | SIGMAR1 (0.56) | SIGMAR1KCNH2KMT2AMEN1 | |
| SCHEMBL8092963 | 0.84 | SIGMAR1 (0.59) | SIGMAR1KCNH2KMT2AMEN1 | |
| SCHEMBL8100061 | 0.83 | MEN1 (0.53) | SIGMAR1KCNH2KMT2AMEN1 | |
| SCHEMBL9372958 | 0.83 | KMT2A (0.67) | SIGMAR1KCNH2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8092627 | 0.81 | SIGMAR1 (0.60) | SIGMAR1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6226287 | 0.79 | MEN1 (0.65) | SIGMAR1KCNH2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |