Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.40 |
| ▸ | MME | P08473 | 6/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292686 | 1.00 | AKT1 (0.40) | AKT1MMEPSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL9337171 | 0.99 | AKT1 (0.39) | AKT1MMEPSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL7292680 | 0.99 | AKT1 (0.39) | AKT1MMEPSEN1PSEN2APH1B | |
| SCHEMBL27349988 | 0.95 | AKT1 (0.41) | AKT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9753598 | 0.85 | MME (0.43) | AKT1MME | |
| SCHEMBL9753601 | 0.85 | MME (0.43) | AKT1MME | |
| SCHEMBL7303613 | 0.84 | AKT1 (0.38) | AKT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9753806 | 0.84 | AKT1 (0.38) | AKT1PSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL9753576 | 0.83 | AKT1 (0.37) | AKT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7321839 | 0.83 | MME (0.45) | MMECTSSITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991010644-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | disclosed |