Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609867 | 0.97 | PTGS1 (0.47) | PTGS1PTGS2GAAKDM4ETDP1 | |
| SCHEMBL7277074 | 0.85 | GAA (0.50) | PTGS1PTGS2GAAKDM4ETDP1 | |
| Methyl Alcohol SCHEMBL9753897 | 0.79 | ALDH1A1 (0.35) | PTGS1PTGS2GAAKDM4ETDP1 | |
| SCHEMBL8607760 | 0.78 | PTGS1 (0.44) | PTGS1PTGS2GAAKDM4ETDP1 | |
| SCHEMBL3306389 | 0.76 | PTGS1 (0.51) | PTGS1PTGS2GAAKDM4ETDP1 | |
| SCHEMBL119926 | 0.76 | GAA (0.66) | PTGS1PTGS2GAAKDM4ETDP1 | |
| SCHEMBL8608780 | 0.76 | PTGS1 (0.42) | PTGS1PTGS2GAAKDM4ETDP1 | |
| SCHEMBL3719434 | 0.76 | MC4R (0.40) | PTGS1PTGS2GAAKDM4ETSHR | |
| SCHEMBL121682 | 0.76 | GAA (0.42) | PTGS1PTGS2GAAKDM4ETDP1 | |
| SCHEMBL8607323 | 0.76 | GAA (0.42) | PTGS1PTGS2GAAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |