Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753505 | 0.93 | PTGS1 (0.42) | PTGS1PTGS2EGLN1APPMETTL3 | |
| SCHEMBL9753496 | 0.81 | APP (0.31) | APP | |
| SCHEMBL9753493 | 0.80 | APP (0.40) | APPKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9753569 | 0.80 | PTGS1 (0.39) | PTGS1PTGS2EGLN1METTL3 | |
| SCHEMBL8608010 | 0.79 | RXFP1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL9753527 | 0.78 | PTGS1 (0.41) | PTGS1PTGS2EGLN1METTL3KDM4E | |
| SCHEMBL8608817 | 0.77 | TBXAS1 (0.49) | PTGS1PTGS2EGLN1APPTBXAS1 | |
| SCHEMBL9753658 | 0.76 | PTGS1 (0.36) | PTGS1PTGS2EGLN1KDM4ELMNA | |
| SCHEMBL8609714 | 0.75 | PTGS1 (0.46) | PTGS1PTGS2EGLN1KDM4EMEN1 | |
| SCHEMBL8605302 | 0.75 | PTGS1 (0.39) | PTGS1PTGS2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |