Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL28174392 | 0.96 | TSHR (0.64) | — | |
| Dimethylformamide SCHEMBL28232017 | 0.96 | TSHR (0.64) | — | |
| Dimethylformamide SCHEMBL28156560 | 0.96 | TSHR (0.64) | — | |
| Dimethylformamide SCHEMBL28869383 | 0.92 | — | — | |
| Dimethylformamide SCHEMBL2692237 | 0.89 | — | — | |
| Dimethylformamide SCHEMBL10370919 | 0.87 | TSHR (0.53) | — | |
| Dimethylformamide SCHEMBL10825078 | 0.86 | TSHR (0.60) | — | |
| Dimethylformamide SCHEMBL8899886 | 0.86 | TSHR (0.60) | — | |
| Dimethylformamide SCHEMBL29212684 | 0.86 | — | — | |
| Dimethylformamide SCHEMBL10800675 | 0.86 | TSHR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609875-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF N-(3-ETHYNYLPHENYL)-7-METHOXY-6-(3-MORPHOLINOPROPOXY) QUINAZOLIN -4-AMINE DIHYDROCHLORIDE | NATCO PHARMA LTD (IN) | 2021-10-20 | — | — | EP | claimed |
| CN-105175407-A | Thiamethoxam and application thereof | ROTAM AGROCHEM INT CO LTD | 2015-12-23 | — | — | CN | disclosed |
| CN-102459272-B | Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use | GENENTECH INC | 2014-08-06 | — | — | CN | disclosed |
| WO-1991015464-A1 | AMIDE ESTER ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1991-10-17 | — | — | WO | disclosed |
| US-4642349-A | REACTING AROMATIC CARBONATE AND ORGANIC HALIDE | THE DOW CHEMICAL COMPANY (US) | 1987-02-10 | — | — | US | disclosed |