Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL9754300 | 0.96 | — | — | |
| Dimethylformamide SCHEMBL28156560 | 0.93 | TSHR (0.64) | TSHRCA1CA2CA9USP2 | |
| Dimethylformamide SCHEMBL28174392 | 0.93 | TSHR (0.64) | TSHRCA1CA2CA9USP2 | |
| Oxalic Acid SCHEMBL8635195 | 0.90 | TSHR (0.60) | TSHRUSP2ALOX15ALDH1A1RECQL | |
| Dimethylformamide SCHEMBL28869383 | 0.89 | — | — | |
| Dimethylformamide SCHEMBL2692237 | 0.86 | — | — | |
| Dimethylformamide SCHEMBL5808716 | 0.84 | — | — | |
| Dimethylformamide SCHEMBL28873647 | 0.84 | TSHR (0.90) | TSHRUSP2ALOX15 | |
| Dimethylformamide SCHEMBL21436169 | 0.84 | — | — | |
| Dimethylformamide SCHEMBL27556220 | 0.84 | TSHR (0.90) | TSHRUSP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106987967-B | A kind of textile fabric with flame-proof antibiotic function | 浙江峰赫纺织有限公司 | 2018-08-21 | — | — | CN | disclosed |