Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.72 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.72 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.72 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.49 |
| ▸ | TUBB | P07437 | 3/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577976 | 0.85 | HDAC7 (1.00) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL1364992 | 0.82 | HDAC1 (0.68) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL13845079 | 0.81 | HDAC7 (0.62) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL2144050 | 0.77 | HDAC6 (0.61) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL1366788 | 0.75 | HDAC6 (0.65) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL1367537 | 0.74 | HDAC6 (0.57) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL2143865 | 0.74 | HDAC6 (0.57) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL1367767 | 0.73 | HDAC6 (0.48) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL1367769 | 0.73 | HDAC6 (0.48) | HDAC7HDAC1HDAC6HDAC4HDAC8 | |
| SCHEMBL11753061 | 0.73 | CES1 (0.66) | HDAC7HDAC1HDAC6HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | HDAC7 7/4885HDAC1 1/4885HDAC6 10/4885 |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | HDAC7 7/4885HDAC1 1/4885HDAC6 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.