Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 12/20 | 0.46 |
| ▸ | MAOA | P21397 | 12/20 | 0.46 |
| ▸ | MAOB | P27338 | 12/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764987 | 0.77 | KDM1A (0.47) | KDM1AMAOAMAOBNFKB1NFKB2 | |
| SCHEMBL8036477 | 0.74 | KDM1A (0.35) | KDM1AMAOAMAOBGAASMN1; SMN2 | |
| SCHEMBL9815393 | 0.73 | MAPT (0.37) | KDM1AMAOAMAOBGAAMAPT | |
| SCHEMBL2018294 | 0.69 | GAA (0.45) | KDM1AMAOAMAOBNFKB1NFKB2 | |
| SCHEMBL10507213 | 0.68 | MAPT (0.50) | KDM1AMAOAMAOBNFKB1NFKB2 | |
| SCHEMBL13742046 | 0.68 | KDM1A (0.58) | KDM1AMAOAMAOB | |
| SCHEMBL8677375 | 0.67 | MAPT (0.53) | KDM1AMAOAMAOBGAAMAPT | |
| SCHEMBL17589053 | 0.66 | KDM1A (0.42) | KDM1AMAOAMAOBGAAMAPT | |
| SCHEMBL5078776 | 0.66 | KDM1A (0.43) | KDM1AMAOAMAOBNFKB1NFKB2 | |
| SCHEMBL10747925 | 0.64 | KDM1A (0.50) | KDM1AMAOAMAOBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991013616-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-09-19 | — | — | WO | disclosed |
| US-4996234-A | Anticholesterol agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-02-26 | — | — | US | disclosed |
| US-4900754-A | ANTICHOLESTEROL AGENTS | RORER PHARMACEUTICAL CORP. (US) | 1990-02-13 | — | — | US | disclosed |