Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 7/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461070 | 0.72 | SLC6A2 (0.60) | SLC6A2ADRA1AHTR2BSLC6A3CYP2D6 | |
| SCHEMBL11487302 | 0.69 | — | — | |
| SCHEMBL30825821 | 0.67 | TSHR (0.42) | SLC6A2CYP2D6KDM4ENPC1CYP1A2 | |
| SCHEMBL30825836 | 0.67 | TSHR (0.42) | SLC6A2CYP2D6KDM4ENPC1CYP1A2 | |
| SCHEMBL2257666 | 0.67 | SLC6A2 (0.58) | SLC6A2ADRA1AHTR2BSLC6A3CYP2D6 | |
| SCHEMBL460150 | 0.67 | SLC6A2 (0.58) | SLC6A2ADRA1AHTR2BSLC6A3CYP2D6 | |
| SCHEMBL20289098 | 0.66 | — | — | |
| SCHEMBL10808421 | 0.64 | — | — | |
| SCHEMBL15187684 | 0.64 | — | — | |
| SCHEMBL11883794 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991007107-A1 | OXAZOLIDINEDIONE HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-05-30 | — | — | WO | disclosed |
| EP-0428312-A2 | Oxazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1991-05-22 | — | — | EP | disclosed |