Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NAAA | Q02083 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924178 | 0.98 | KDM4E (1.00) | KDM4EKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3614618 | 0.98 | KDM4E (1.00) | KDM4EKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL18896226 | 0.98 | KDM4E (1.00) | KDM4EKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL20152243 | 0.98 | KDM4E (1.00) | KDM4EKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6359528 | 0.95 | KDM4E (0.88) | KDM4EKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL27650606 | 0.93 | KDM4E (0.89) | KDM4EKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6360168 | 0.89 | KDM4E (0.77) | KDM4EKMT2ASMN1; SMN2NPC1RAB9A | |
| Formamide SCHEMBL8056562 | 0.88 | KDM4E (0.77) | KDM4EKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL30096713 | 0.85 | KDM4E (0.72) | KDM4EKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL13197134 | 0.84 | KDM4E (0.71) | KDM4EKMT2ASMN1; SMN2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005771-A1 | LIPOPHILIC ACYLPYRAZINAMIDE PRODRUGS | SCHREIER HANS (US) | 1991-05-02 | — | — | WO | claimed |
| EP-2069354-B1 | Aza-benzofuranyl compounds and methods of use | GENENTECH INC (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-1991005771-A1 | LIPOPHILIC ACYLPYRAZINAMIDE PRODRUGS | SCHREIER HANS (US) | 1991-05-02 | — | — | WO | disclosed |
| WO-1991005771-A1 | LIPOPHILIC ACYLPYRAZINAMIDE PRODRUGS | SCHREIER HANS (US) | 1991-05-02 | — | — | WO | disclosed |