Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.33 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.67 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.67 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL28449741 | 0.93 | — | — | |
| Glycine SCHEMBL27918502 | 0.90 | — | — | |
| Glycine SCHEMBL8585762 | 0.89 | GLRA1 (0.83) | OR51E2GLRA1SLC6A9FFAR3GABRR1 | |
| Glycine SCHEMBL20295 | 0.89 | — | — | |
| Glycine SCHEMBL21879657 | 0.89 | GLRA1 (0.83) | OR51E2GLRA1SLC6A9FFAR3GABRR1 | |
| Glycine SCHEMBL5569329 | 0.89 | — | — | |
| Glycine SCHEMBL6239942 | 0.89 | GLRA1 (0.83) | OR51E2GLRA1SLC6A9FFAR3GABRR1 | |
| Glycine SCHEMBL6853447 | 0.89 | GLRA1 (0.83) | OR51E2GLRA1SLC6A9FFAR3GABRR1 | |
| Glycine SCHEMBL6511637 | 0.86 | — | — | |
| Glycine SCHEMBL2361724 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991013091-A1 | CRYOPERSERVATION OF RED BLOOD CELLS | AGOURON PHARMACEUTICALS, INC. (US) | 1991-09-05 | — | — | WO | disclosed |