SCHEMBL9755897

SCHEMBL9755897

COc1ccccc1C(=O)N(NC(=O)CCc1ccccc1)C(C)(C)C

nearest known ligand 0.65

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.48
KDM4E B2RXH2 1/20 0.46
TP53 P04637 1/20 0.46
GLA P06280 1/20 0.46
HPGD P15428 1/20 0.46
KMT2A Q03164 1/20 0.46
GPR52 Q9Y2T5 1/20 0.45
TAAR1 Q96RJ0 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9756161 0.93 HPGD (0.53) LMNAHPGD
SCHEMBL9756047 0.92 HPGD (0.49) LMNAHPGD
SCHEMBL9755916 0.89 MEN1 (0.53) LMNATP53GLAHPGDKMT2A
SCHEMBL9756008 0.86 MAPT (0.46)
SCHEMBL9755896 0.84 ALDH1A1 (0.48)
SCHEMBL9755953 0.84 HDAC1 (0.45) LMNA
SCHEMBL9756344 0.84 ABCB1 (0.51)
SCHEMBL9756326 0.83 HDAC8 (0.49) SMN1; SMN2
SCHEMBL9756087 0.82 HDAC8 (0.51) L3MBTL1SMN1; SMN2
SCHEMBL9756022 0.82 HDAC8 (0.51) L3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0234944-B1 INSECTICIDAL N'-SUBSTITUTED-N-ACYL-N'-ALKYLCARBONYLHYDRAZINES ROHM AND HAAS COMPANY (US) 1991-04-10 EP disclosed
EP-0232075-B1 INSECTICIDAL N'-SUBSTITUTED-N-ALKYLCARBONYL-N'-ACYL HYDRAZINES ROHM AND HAAS COMPANY (US) 1991-03-13 EP disclosed
EP-0232075-A1 Insecticidal N'-substituted-N-alkylcarbonyl-N'-acyl hydrazines ROHM AND HAAS COMPANY (US) 1987-08-12 EP disclosed