Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756803 | 1.00 | ALDH1A1 (0.47) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL11404737 | 0.83 | ALDH1A1 (0.52) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL28349380 | 0.80 | ALDH1A1 (0.46) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL28986139 | 0.79 | AOC3 (0.50) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL3650058 | 0.77 | ALDH1A1 (0.46) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL7624337 | 0.76 | ALDH1A1 (0.47) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL11790236 | 0.75 | ALDH1A1 (0.47) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL9756769 | 0.75 | SMN1; SMN2 (0.48) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL4732176 | 0.74 | ALDH1A1 (0.54) | ALDH1A1GLATSHRSMN1; SMN2MEN1 | |
| SCHEMBL3649130 | 0.74 | ALDH1A1 (0.46) | ALDH1A1GLATSHRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0316374-B1 | OPTICALLY ACTIVE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-31 | — | — | EP | disclosed |
| EP-0316374-A1 | OPTICALLY ACTIVE COMPOUNDS. | HOFFMANN LA ROCHE (CH) | 1989-05-24 | — | — | EP | disclosed |
| WO-1988008838-A1 | OPTICALLY ACTIVE COMPOUNDS | F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1988-11-17 | — | — | WO | disclosed |