Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.69 |
| ▸ | CYSLTR2 | Q9NS75 | 12/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756949 | 1.00 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2MEN1KMT2ARAB9A | |
| SCHEMBL10402601 | 0.87 | CYSLTR2 (0.67) | CYSLTR1CYSLTR2MEN1KMT2ARAB9A | |
| SCHEMBL10402603 | 0.87 | CYSLTR2 (0.67) | CYSLTR1CYSLTR2MEN1KMT2ARAB9A | |
| SCHEMBL10405745 | 0.86 | CYSLTR2 (0.52) | CYSLTR1CYSLTR2MEN1KMT2ARAB9A | |
| SCHEMBL10405746 | 0.86 | CYSLTR2 (0.52) | CYSLTR1CYSLTR2MEN1KMT2ARAB9A | |
| SCHEMBL10402152 | 0.84 | CYSLTR1 (0.65) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL10402153 | 0.84 | CYSLTR1 (0.65) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL10401682 | 0.83 | CYSLTR1 (0.81) | CYSLTR1CYSLTR2MEN1KMT2AABCC1 | |
| SCHEMBL10401689 | 0.83 | CYSLTR1 (0.81) | CYSLTR1CYSLTR2MEN1KMT2AABCC1 | |
| SCHEMBL10402879 | 0.82 | CYSLTR1 (0.79) | CYSLTR1CYSLTR2MEN1KMT2AABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |