Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757196 | 0.80 | GPBAR1 (0.49) | GPBAR1PDE10ACYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9757014 | 0.80 | GPBAR1 (0.48) | GPBAR1PDE10ACYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9756950 | 0.79 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL9757087 | 0.79 | CYSLTR1 (0.54) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9756961 | 0.73 | FFAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL9757212 | 0.73 | GPBAR1 (0.60) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL9757113 | 0.72 | CYSLTR1 (0.50) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL421067 | 0.72 | GPBAR1 (1.00) | GPBAR1PDE10ACYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL9581634 | 0.71 | GPBAR1 (0.97) | GPBAR1PDE10ACYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL9581618 | 0.71 | GPBAR1 (0.97) | GPBAR1PDE10ACYSLTR1CYSLTR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |