Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756950 | 0.85 | GPBAR1 (0.48) | GPBAR1CYSLTR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL9757014 | 0.84 | GPBAR1 (0.48) | GPBAR1CYSLTR1FFAR1AKR1B1PDE10A | |
| SCHEMBL9756958 | 0.80 | GPBAR1 (0.53) | GPBAR1CYSLTR1FFAR1AKR1B1PDE10A | |
| SCHEMBL9757087 | 0.79 | CYSLTR1 (0.54) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9757199 | 0.79 | CYSLTR1 (0.48) | GPBAR1CYSLTR1FFAR1AKR1B1PDE10A | |
| SCHEMBL9757113 | 0.76 | CYSLTR1 (0.50) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9757212 | 0.75 | GPBAR1 (0.60) | GPBAR1CYSLTR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL9756961 | 0.74 | FFAR1 (0.48) | GPBAR1CYSLTR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL7012874 | 0.73 | GPBAR1 (0.66) | GPBAR1CYSLTR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL9635485 | 0.70 | CYSLTR1 (0.55) | GPBAR1CYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |