Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 4/20 | 0.59 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757389 | 0.87 | PSMB8 (0.59) | PSMB8PSMB5SMN1; SMN2NPC1RAB9A | |
| Bromide SCHEMBL9757330 | 0.75 | PSMB8 (0.50) | PSMB8PSMB5SMN1; SMN2LMNATP53 | |
| SCHEMBL1162063 | 0.75 | MAPT (0.35) | PSMB8PSMB5PIK3CGSMN1; SMN2NPC1 | |
| SCHEMBL1390803 | 0.75 | POLB (0.44) | SMN1; SMN2NPC1USP2RAB9AMAPK10 | |
| SCHEMBL9757128 | 0.75 | PSMB8 (0.65) | PSMB8PSMB5NPC1RAB9ACYP19A1 | |
| SCHEMBL21689039 | 0.75 | PSMB8 (0.65) | PSMB8PSMB5PIK3CGSMN1; SMN2NPC1 | |
| SCHEMBL9757252 | 0.75 | PSMB8 (0.65) | PSMB8PSMB5SMN1; SMN2NPC1USP2 | |
| SCHEMBL9797527 | 0.74 | PSMB8 (0.63) | PSMB8PSMB5PIK3CGMAPTMAPK1 | |
| SCHEMBL9797235 | 0.73 | PSMB8 (0.61) | PSMB8PSMB5PIK3CGMAPTMAPK1 | |
| SCHEMBL30058638 | 0.71 | PSMB8 (0.59) | PSMB8PSMB5SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |