Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.72 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.48 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.48 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757052 | 1.00 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL13513030 | 0.90 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL8303664 | 0.84 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL8303662 | 0.84 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL6090473 | 0.84 | CYSLTR2 (1.00) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL6090471 | 0.84 | CYSLTR2 (1.00) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL10421429 | 0.84 | KDM4E (0.65) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL10421430 | 0.84 | KDM4E (0.65) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL6750524 | 0.83 | KDM4E (0.67) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 | |
| SCHEMBL10402117 | 0.83 | CYSLTR2 (0.72) | CYSLTR1CYSLTR2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4962203-A | ANTIASTHMATIC, ANTIALLERGENIC, ANTIINFLAMMATORY AND CYTOPROTECTIVE AGENTS | MERCK FROST CANADA, INC. (CA) | 1990-10-09 | — | — | US | disclosed |
| EP-0206751-A2 | 2-Substituted quinolines, their preparation and use | MERCK FROSST CANADA INC. (CA) | 1986-12-30 | — | — | EP | disclosed |