Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.46 |
| ▸ | ABCC2 | Q92887 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.46 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303662 | 1.00 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL13513030 | 0.91 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL6750524 | 0.84 | KDM4E (0.67) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL9757052 | 0.84 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL6990449 | 0.84 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL8783716 | 0.84 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL8746348 | 0.84 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL919524 | 0.84 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL9757059 | 0.84 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2KDM4ENPC1LMNA | |
| SCHEMBL919522 | 0.84 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2KDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| EP-0658554-A1 | N-benzyl dihydroindole LTD4 antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |