SCHEMBL9758652

SCHEMBL9758652

CCCCCCCC1CCC(F)(c2ccc(CCC)cc2)CC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
SPHK1 Q9NYA1 6/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2C8 P10632 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
S1PR3 Q99500 1/20 0.37
ITGB3 P05106 1/20 0.36
ITGA2B P08514 1/20 0.36
CYP1A2 P05177 1/20 0.35
ESR1 P03372 2/20 0.35
ADRA2A P08913 2/20 0.35
ADORA3 P0DMS8 2/20 0.35
TACR2 P21452 2/20 0.35
SLC6A2 P23975 2/20 0.35
SLC6A4 P31645 2/20 0.35
SLC6A3 Q01959 2/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9757785 0.99 MAOA (0.38) MAOAMAOBSPHK1CYP3A4CYP2C8
SCHEMBL9758966 0.96 TSHR (0.37) MAOAMAOBSPHK1CYP3A4CYP2C8
SCHEMBL9757852 0.95 MAOA (0.36) MAOAMAOBSPHK1CYP3A4CYP2C8
SCHEMBL9757952 0.94 SPHK1 (0.43) SPHK1CYP3A4S1PR3ITGB3ITGA2B
SCHEMBL9759087 0.94 CYP1A2 (0.41) MAOAMAOBSPHK1CYP1A2BCHE
SCHEMBL9759568 0.93 SPHK1 (0.40) SPHK1CYP3A4ITGB3ITGA2BESR1
SCHEMBL9758033 0.90 CYP1A2 (0.38) MAOAMAOBCYP1A2ALDH1A1HSD17B10
SCHEMBL9759330 0.90 SPHK1 (0.40) SPHK1CYP3A4ITGB3ITGA2BCYP1A2
SCHEMBL9758978 0.88 MAOA (0.40) MAOAMAOBCYP2C9HTR2CHTR2A
SCHEMBL9759834 0.87 SPHK1 (0.40) SPHK1CYP3A4ESR1ADRA2AADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4985583-A Liquid Crystals MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-01-15 US disclosed
EP-0154849-A2 Cyclohexane derivatives MERCK PATENT GmbH (DE) 1985-09-18 EP disclosed