Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | BID | P55957 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949124 | 0.84 | LIPG (0.50) | LIPGCYP3A4ALOX5PTGS2BID | |
| SCHEMBL6955322 | 0.84 | LIPG (0.50) | LIPGCYP3A4ALOX5PTGS2BID | |
| SCHEMBL5763437 | 0.80 | CLCN2 (0.41) | HTT | |
| SCHEMBL6955710 | 0.80 | CYP3A4 (0.42) | LIPGCYP3A4CYP2D6CYP2C9ALOX5 | |
| SCHEMBL1078217 | 0.79 | LIPG (0.51) | LIPGCYP3A4CYP2D6CYP2C9ALOX5 | |
| SCHEMBL27690336 | 0.79 | LIPG (0.51) | LIPGBIDMCL1BCL2L1BAK1 | |
| SCHEMBL27813777 | 0.78 | LIPG (0.54) | LIPGCYP3A4ALOX5PTGS2BID | |
| SCHEMBL10619679 | 0.78 | LIPG (0.54) | LIPGCYP3A4ALOX5PTGS2BID | |
| SCHEMBL9136286 | 0.77 | LIPG (0.49) | LIPGCYP2D6CYP2C9ALOX5PTGS2 | |
| SCHEMBL11781845 | 0.75 | LIPG (0.51) | LIPGCYP3A4ALOX5PTGS2BID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184277-B1 | ARYL PYRIMIDINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | INST PHARM & TOXICOLOGY AMMS (CN) | 2015-07-01 | — | — | EP | disclosed |
| US-8759355-B2 | Aryl pyrimidine derivatives, preparation methods and pharmaceutical uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. (CN) | 2014-06-24 | — | — | US | disclosed |
| US-20110009427-A1 | ARYL PYRIMIDINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | INSTITUE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2011-01-13 | — | — | US | disclosed |
| EP-2184277-A1 | ARYL PYRIMIDINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China (CN) | 2010-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009427-A1 | ARYL PYRIMIDINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | PPARD, PPARG, PPARA | LIPG 785/4885CYP3A4 222/4885CYP2D6 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.