Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | SLC16A3 | O15427 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30637100 | 1.00 | FOLH1 (0.61) | FOLH1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL9861570 | 0.93 | MAPT (0.59) | FOLH1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL503904 | 0.93 | MAPT (0.59) | FOLH1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8698719 | 0.90 | TSHR (0.50) | FOLH1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL29062 | 0.88 | FOLH1 (0.66) | FOLH1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL31474045 | 0.88 | FOLH1 (0.70) | FOLH1SMN1; SMN2SLC16A3ALDH1A1ALOX15 | |
| SCHEMBL729909 | 0.88 | FOLH1 (0.70) | FOLH1SMN1; SMN2SLC16A3ALDH1A1ALOX15 | |
| SCHEMBL9345842 | 0.86 | FOLH1 (0.68) | FOLH1SLC16A3ALDH1A1ALOX15TSHR | |
| SCHEMBL31512109 | 0.86 | HDAC3 (0.68) | HDAC3MAPK1ADRA1AHDAC4SLC6A3 | |
| SCHEMBL2878880 | 0.86 | HDAC3 (0.68) | HDAC3MAPK1ADRA1AHDAC4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522595-A2 | CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS | The Scripps Research Institute (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220559-A2 | CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220559-A2 | CATALYST-CONTROLLED SITE-SELECTIVE METHYLENE C-H LACTONIZATION OF DICARBOXYLIC ACIDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-11-16 | — | — | WO | disclosed |
| EP-2714648-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-08-16 | — | — | EP | disclosed |
| CN-103748070-B | Enkephalinase inhibitors | THERAVANCE INC | 2015-06-24 | — | — | CN | disclosed |
| US-20120308588-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | US | disclosed |
| WO-2012166389-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | WO | disclosed |
| US-5061490-A | FOSTERING GROWTH OF CORN PLANTS | W. R. GRACE & CO.-CONN. (US) | 1991-10-29 | — | — | US | disclosed |
| US-4021408-A | DYES, PESTICIDES, STABILIZERS FOR POLYMERS | BASF AKTIENGESELLSCHAFT (DT) | 1977-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120308588-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | FOLH1 1070/4885HDAC3 599/4885MAPK1 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.