Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 6/20 | 0.79 |
| ▸ | HTR3A | P46098 | 5/20 | 0.79 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.60 |
| ▸ | HTR3B | O95264 | 2/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.60 |
| ▸ | HTR5A | P47898 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721653 | 1.00 | HTR4 (0.79) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9759843 | 1.00 | HTR4 (0.79) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9721666 | 1.00 | HTR4 (0.79) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9721646 | 1.00 | HTR4 (0.79) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| Norcisapride SCHEMBL8245159 | 0.88 | HTR4 (1.00) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| Ticalopride SCHEMBL17208 | 0.88 | HTR4 (1.00) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| Norcisapride SCHEMBL734363 | 0.88 | HTR4 (1.00) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| Norcisapride SCHEMBL3319911 | 0.88 | HTR4 (1.00) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| Norcisapride SCHEMBL3317329 | 0.88 | HTR4 (1.00) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL166820 | 0.88 | HTR4 (0.77) | HTR4HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041454-A | Stimulate gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |
| US-4990521-A | Treating diarhea | JANSSEN PHARMACEUTICA (BE) | 1991-02-05 | — | — | US | disclosed |
| US-4975439-A | Gastrointestinal motility stimulating properties | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-12-04 | — | — | US | disclosed |
| EP-0251417-A2 | 4-(aroylamino) piperidinebutanamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-01-07 | — | — | EP | disclosed |