SCHEMBL9760252

SCHEMBL9760252

CCOC(=O)C1=C(COCCCOCCCN)NC(C)=C(C(=O)OC)[C@H]1c1cccc(C(F)(F)F)c1SC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.58
ADRA2A P08913 2/20 0.58
CHRM1 P11229 2/20 0.58
DRD1 P21728 2/20 0.58
TBXA2R P21731 2/20 0.58
SLC6A2 P23975 2/20 0.58
ADRA1A P35348 2/20 0.58
OPRM1 P35372 2/20 0.58
DRD3 P35462 2/20 0.58
SLC6A3 Q01959 2/20 0.58
KCNH2 Q12809 2/20 0.58
CACNA1C Q13936 2/20 0.58
KCNK2 O95069 1/20 0.58
ABCB11 O95342 1/20 0.58
ADRB2 P07550 1/20 0.58
ABCB1 P08183 1/20 0.58
ADORA3 P0DMS8 1/20 0.58
ADRB3 P13945 1/20 0.58
DRD2 P14416 1/20 0.58
ADRA2C P18825 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9760257 1.00 HTR1A (0.58) HTR1AADRA2ACHRM1DRD1TBXA2R
Fumaric Acid SCHEMBL9760005 0.96 HTR1A (0.54) HTR1AADRA2ACHRM1DRD1TBXA2R
Fumaric Acid SCHEMBL9760020 0.96 HTR1A (0.54) HTR1AADRA2ACHRM1DRD1TBXA2R
SCHEMBL7291670 0.82 TBXA2R (0.74) HTR1AADRA2ACHRM1DRD1TBXA2R
SCHEMBL9760016 0.81 CACNA1C (0.37) HTR1AADRA2ACHRM1DRD1TBXA2R
Fumaric Acid SCHEMBL9760027 0.79 HTR1A (0.67) HTR1AADRA2ACHRM1DRD1TBXA2R
Fumaric Acid SCHEMBL9760046 0.79 HTR1A (0.67) HTR1AADRA2ACHRM1DRD1TBXA2R
SCHEMBL10743956 0.78 HTR1A (0.63) HTR1AADRA2ACHRM1DRD1TBXA2R
Fumaric Acid SCHEMBL9760654 0.78 TBXA2R (0.68) HTR1AADRA2ACHRM1DRD1TBXA2R
Fumaric Acid SCHEMBL9760678 0.78 TBXA2R (0.68) HTR1AADRA2ACHRM1DRD1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5026863-A Medicinal products in racemic or enantiomorph form; calcium channel blockers. hypotensive agents, cardiovascular disorders ADIR ET COMPAGNIE (FR) 1991-06-25 US disclosed
US-4983740-A Multistep; from 2- 2-/2-chloroethoxy/ethoxy!ethanol and potassium phthalimide ADIR ET COMPAGNIE (FR) 1991-01-08 US disclosed
US-4870091-A CALCIUM CHANNEL BLOCKERS ADIR ET CIE (FR) 1989-09-26 US disclosed