Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 16/20 | 0.56 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102450 | 0.77 | CYP19A1 (0.53) | CYP19A1CYP26A1CYP3A4CYP11B1TSHR | |
| SCHEMBL13292485 | 0.75 | CYP19A1 (1.00) | CYP19A1CYP26A1CYP3A4CYP11B1TSHR | |
| SCHEMBL14565226 | 0.74 | CYP19A1 (0.56) | CYP19A1CYP26A1CYP3A4CYP11B1TSHR | |
| SCHEMBL10102510 | 0.74 | CYP19A1 (0.49) | CYP19A1CYP26A1CYP11B1KDM4E | |
| SCHEMBL9524108 | 0.72 | CYP19A1 (0.60) | CYP19A1CYP26A1CYP3A4CYP11B1TSHR | |
| SCHEMBL12337077 | 0.72 | CYP19A1 (0.49) | CYP19A1CYP26A1CYP11B1KDM4E | |
| SCHEMBL9761076 | 0.72 | KDM4E (0.50) | KDM4ECA12PARP1CA9 | |
| SCHEMBL7413890 | 0.71 | CYP19A1 (0.83) | CYP19A1CYP26A1CYP3A4CYP11B1TSHR | |
| SCHEMBL9760022 | 0.70 | CYP19A1 (0.56) | CYP19A1CYP26A1CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL11367077 | 0.69 | CYP19A1 (0.79) | CYP19A1CYP26A1CYP3A4CYP11B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |