Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | PARP1 | P09874 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028635 | 0.82 | CA12 (0.50) | KDM4EPARP1CA12CA9PDE3A | |
| SCHEMBL7032963 | 0.80 | CA12 (0.47) | KDM4EPARP1CA12CA9PDE3A | |
| SCHEMBL7026218 | 0.77 | CA12 (0.45) | KDM4EPARP1CA12CA9PDE3A | |
| SCHEMBL7030965 | 0.76 | KDM4E (0.50) | KDM4EPARP1CA12CA9PDE3A | |
| SCHEMBL8900615 | 0.72 | PDE3A (0.62) | KDM4EPARP1CA12CA9PDE3A | |
| SCHEMBL9760910 | 0.72 | CYP19A1 (0.56) | KDM4EPARP1CA12CA9 | |
| SCHEMBL10102395 | 0.71 | BRD4 (0.55) | KDM4EALDH1A1HPGDBRD4HSD17B10 | |
| SCHEMBL18020134 | 0.70 | PDE3A (0.59) | KDM4EPARP1CA12CA9PDE3A | |
| SCHEMBL404118 | 0.70 | PARP1 (0.56) | KDM4EPARP1CA12CA9ALDH1A1 | |
| SCHEMBL7035473 | 0.69 | PARP1 (0.48) | KDM4EPARP1CA12CA9PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |