Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.53 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.53 |
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 0.53 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.53 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.53 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.53 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.53 |
| ▸ | OPRD1 known ✓ | P41143 | 2/20 | 0.53 |
| ▸ | ADRB3 known ✓ | P13945 | 2/20 | 0.53 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.53 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.53 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.53 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.53 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760884 | 0.86 | TBXA2R (0.66) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| SCHEMBL9760878 | 0.86 | TBXA2R (0.66) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| SCHEMBL7291670 | 0.84 | TBXA2R (0.74) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| SCHEMBL7426471 | 0.84 | CACNA1C (0.55) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| Fumaric Acid SCHEMBL9761229 | 0.84 | CACNA1C (0.57) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| Fumaric Acid SCHEMBL9761213 | 0.84 | CACNA1C (0.57) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| Fumaric Acid SCHEMBL9761314 | 0.83 | TBXA2R (0.61) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| Fumaric Acid SCHEMBL9761329 | 0.83 | TBXA2R (0.61) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| Olradipine SCHEMBL30357967 | 0.82 | TBXA2R (0.74) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C | |
| Olradipine SCHEMBL29711094 | 0.82 | TBXA2R (0.74) | TBXA2RSLC6A3KCNH2ADRA1ACACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026863-A | Medicinal products in racemic or enantiomorph form; calcium channel blockers. hypotensive agents, cardiovascular disorders | ADIR ET COMPAGNIE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-4983740-A | Multistep; from 2- 2-/2-chloroethoxy/ethoxy!ethanol and potassium phthalimide | ADIR ET COMPAGNIE (FR) | 1991-01-08 | — | — | US | disclosed |
| US-4870091-A | CALCIUM CHANNEL BLOCKERS | ADIR ET CIE (FR) | 1989-09-26 | — | — | US | disclosed |