Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.82 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.82 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CDC25B | P30305 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolrestat SCHEMBL49326 | 0.90 | AKR1B10 (1.00) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| Tolrestat SCHEMBL29375449 | 0.90 | AKR1B10 (1.00) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| Tolrestat SCHEMBL20769758 | 0.90 | AKR1B10 (1.00) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| Tolrestat SCHEMBL10391297 | 0.89 | AKR1B10 (0.98) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL10352891 | 0.89 | AKR1B10 (0.82) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| Tolrestat SCHEMBL10391296 | 0.89 | AKR1B10 (0.82) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL10352845 | 0.89 | AKR1B10 (0.65) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL10352853 | 0.89 | AKR1B10 (0.74) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL10352852 | 0.87 | AKR1B10 (0.79) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL10352848 | 0.85 | AKR1B10 (0.74) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206546-B1 | N-[(1-naphthalenyl)-thioxomethyl and carbonyl]-N-methylglycinamide derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-08 | — | — | EP | claimed |
| US-4853484-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | claimed |
| US-4734435-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORP. (US) | 1988-03-29 | — | — | US | claimed |
| EP-0241144-A1 | Naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-10-14 | — | — | EP | claimed |
| US-4672058-A | N[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl]-N-methylglycinamides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | claimed |
| EP-0206546-A2 | N-[(1-naphthalenyl)-thioxomethyl and carbonyl]-N-methylglycinamide derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-12-30 | — | — | EP | claimed |
| US-4994381-A | Fermentation of Streptomyces | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |
| US-4853484-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | disclosed |
| US-4841035-A | HERBICIDES | TOYO SODA MFG. CO. (JP) | 1989-06-20 | — | — | US | disclosed |
| US-4734435-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORP. (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0241144-A1 | Naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |
| US-4672058-A | N[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl]-N-methylglycinamides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| US-4672058-A | N[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl]-N-methylglycinamides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| US-4672059-A | ENZYME INHIBITORS; PREVENT OR TREAT DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |